[HTML][HTML] C1q/TNF-related protein 4 (CTRP4) is a unique secreted protein with two tandem C1q domains that functions in the hypothalamus to modulate food intake …
MS Byerly, PS Petersen, S Ramamurthy… - Journal of Biological …, 2014 - ASBMB
CTRP4 is a unique member of the C1q family, possessing two tandem globular C1q
domains. Its physiological function is poorly defined. Here, we show that CTRP4 is an
evolutionarily conserved,∼ 34-kDa secretory protein expressed in the brain. In human,
mouse, and zebrafish brain, CTRP4 expression begins early in development and is
widespread in the central nervous system. Neurons, but not astrocytes, express and secrete
CTRP4, and secreted proteins form higher-order oligomeric complexes. CTRP4 is also …
domains. Its physiological function is poorly defined. Here, we show that CTRP4 is an
evolutionarily conserved,∼ 34-kDa secretory protein expressed in the brain. In human,
mouse, and zebrafish brain, CTRP4 expression begins early in development and is
widespread in the central nervous system. Neurons, but not astrocytes, express and secrete
CTRP4, and secreted proteins form higher-order oligomeric complexes. CTRP4 is also …