Quantifying HIV-1-mediated gut CD4+ T cell death in the Lamina Propria aggregate culture (LPAC) model
Gut CD4 T cells are major targets of HIV-1 and are massively depleted early during infection.
To better understand the mechanisms governing HIV-1-mediated CD4 T cell death, we
developed the physiologically-relevant Lamina Propria Aggregate Culture (LPAC) model.
The LPAC model is ideal for studying CD4 T cell death induced by clinically-relevant
Transmitted/Founder (TF) HIV-1 strains and is also suitable for studying how enteric
microbes and soluble factors (eg, Type I Interferons) impact LP CD4 T cell death and …
To better understand the mechanisms governing HIV-1-mediated CD4 T cell death, we
developed the physiologically-relevant Lamina Propria Aggregate Culture (LPAC) model.
The LPAC model is ideal for studying CD4 T cell death induced by clinically-relevant
Transmitted/Founder (TF) HIV-1 strains and is also suitable for studying how enteric
microbes and soluble factors (eg, Type I Interferons) impact LP CD4 T cell death and …