Characterization of the antibody response in mice with type II collagen–induced arthritis, using monoclonal anti–type II collagen antibodies
Arthritis & Rheumatism: Official Journal of the American College …, 1986•Wiley Online Library
Twenty monoclonal antibodies reactive with type II collagen were characterized as to their
determinant specificity and their reactivity with cartilage‐derived components. The
monoclonal antibodies reacted with 7 different epitopes on the native type II collagen triple
helical structure. Antibodies defining 3 of these epitopes occurred more frequently in sera
from arthritic mice than in sera from nonarthritic mice. In vivo injection of some selected
autoreactive antibodies caused synovitis, but in no case did it give rise to full‐blown arthritis.
determinant specificity and their reactivity with cartilage‐derived components. The
monoclonal antibodies reacted with 7 different epitopes on the native type II collagen triple
helical structure. Antibodies defining 3 of these epitopes occurred more frequently in sera
from arthritic mice than in sera from nonarthritic mice. In vivo injection of some selected
autoreactive antibodies caused synovitis, but in no case did it give rise to full‐blown arthritis.
Abstract
Twenty monoclonal antibodies reactive with type II collagen were characterized as to their determinant specificity and their reactivity with cartilage‐derived components. The monoclonal antibodies reacted with 7 different epitopes on the native type II collagen triple helical structure. Antibodies defining 3 of these epitopes occurred more frequently in sera from arthritic mice than in sera from nonarthritic mice. In vivo injection of some selected autoreactive antibodies caused synovitis, but in no case did it give rise to full‐blown arthritis.
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