Microbial influences of mucosal immunity in rheumatoid arthritis
TM Wilson, B Trent, KA Kuhn… - Current rheumatology …, 2020 - Springer
TM Wilson, B Trent, KA Kuhn, MK Demoruelle
Current rheumatology reports, 2020•SpringerAbstract Purpose of Review This review will summarize recent data defining the relationship
between rheumatoid arthritis (RA) and the microbiome at mucosal sites throughout the body.
It will highlight what is known, what is speculated, and current knowledge gaps regarding
the microbiome in RA. Recent Findings An extensive relationship between the microbiome
and immune cell function can influence RA-related inflammation and T cell and B cell
biology. Studies are beginning to characterize microbial changes in individuals who are at …
between rheumatoid arthritis (RA) and the microbiome at mucosal sites throughout the body.
It will highlight what is known, what is speculated, and current knowledge gaps regarding
the microbiome in RA. Recent Findings An extensive relationship between the microbiome
and immune cell function can influence RA-related inflammation and T cell and B cell
biology. Studies are beginning to characterize microbial changes in individuals who are at …
Purpose of Review
This review will summarize recent data defining the relationship between rheumatoid arthritis (RA) and the microbiome at mucosal sites throughout the body. It will highlight what is known, what is speculated, and current knowledge gaps regarding the microbiome in RA.
Recent Findings
An extensive relationship between the microbiome and immune cell function can influence RA-related inflammation and T cell and B cell biology. Studies are beginning to characterize microbial changes in individuals who are at risk for RA, which is a critical element needed to understand the influence of the microbiome on RA pathogenesis.
Summary
Expanding our understanding of the microbiome in RA beyond the bacteria at the gut and oral mucosae into the lung and urogenital surfaces, including viral and fungal components, and establishing the relationship across mucosal sites will be critical in future work. Importantly, approaches to manipulate the microbiome could lead to novel therapeutic and preventive strategies.
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