Store-operated calcium entry: Mechanisms and modulation
PG Hogan, A Rao - Biochemical and biophysical research communications, 2015 - Elsevier
PG Hogan, A Rao
Biochemical and biophysical research communications, 2015•ElsevierStore-operated calcium entry is a central mechanism in cellular calcium signalling and in
maintaining cellular calcium balance. This review traces the history of research on store-
operated calcium entry, the discovery of STIM and ORAI as central players in calcium entry,
and the role of STIM and ORAI in biology and human disease. It describes current
knowledge of the basic mechanism of STIM-ORAI signalling and of the varied mechanisms
by which STIM-ORAI signalling can be modulated.
maintaining cellular calcium balance. This review traces the history of research on store-
operated calcium entry, the discovery of STIM and ORAI as central players in calcium entry,
and the role of STIM and ORAI in biology and human disease. It describes current
knowledge of the basic mechanism of STIM-ORAI signalling and of the varied mechanisms
by which STIM-ORAI signalling can be modulated.
Abstract
Store-operated calcium entry is a central mechanism in cellular calcium signalling and in maintaining cellular calcium balance. This review traces the history of research on store-operated calcium entry, the discovery of STIM and ORAI as central players in calcium entry, and the role of STIM and ORAI in biology and human disease. It describes current knowledge of the basic mechanism of STIM-ORAI signalling and of the varied mechanisms by which STIM-ORAI signalling can be modulated.
Elsevier