[HTML][HTML] A20 blocks endothelial cell activation through a NF-κB-dependent mechanism
JT Cooper, DM Stroka, C Brostjan… - Journal of Biological …, 1996 - ASBMB
The A20 gene product is a novel zinc finger protein originally described as a tumor necrosis
factor α (TNF)-inducible early response gene in human umbilical vein endothelial cells
(HUVEC). Its described function is to block TNF-induced apoptosis in fibroblasts and B
lymphocytes, but more recently it has also been shown to play a role in lymphoid cell
maturation. The mechanism of action of A20 is unknown. The aim of our study was to assess
the effect of A20 upon endothelial cell activation. By transfecting bovine aortic endothelial …
factor α (TNF)-inducible early response gene in human umbilical vein endothelial cells
(HUVEC). Its described function is to block TNF-induced apoptosis in fibroblasts and B
lymphocytes, but more recently it has also been shown to play a role in lymphoid cell
maturation. The mechanism of action of A20 is unknown. The aim of our study was to assess
the effect of A20 upon endothelial cell activation. By transfecting bovine aortic endothelial …