[HTML][HTML] Transcriptional Regulation of the Intercellular Adhesion Molecule-1 Gene by Inflammatory Cytokines in Human Endothelial Cells: ESSENTIAL ROLES OF A …
HC Ledebur, TP Parks - Journal of Biological Chemistry, 1995 - ASBMB
Intercellular adhesion molecule-1 (ICAM-1) is greatly up-regulated on endothelial cells at
sites of inflammation and is involved in leukocyte attachment and extravasation. Previously,
we had shown that the ICAM-1 gene expression in human umbilical vein endothelial cells
(HUVECs) was transcriptionally regulated by tumor necrosis factor-α (TNF-α)(Wertheimer,
SJ, Myers, CL, Wallace, RW, and Parks, TP (1992) J. Biol. Chem. 267, 12030-12035). In the
present investigation, TNF-αinduced transcription was found to be initiated exclusively at two …
sites of inflammation and is involved in leukocyte attachment and extravasation. Previously,
we had shown that the ICAM-1 gene expression in human umbilical vein endothelial cells
(HUVECs) was transcriptionally regulated by tumor necrosis factor-α (TNF-α)(Wertheimer,
SJ, Myers, CL, Wallace, RW, and Parks, TP (1992) J. Biol. Chem. 267, 12030-12035). In the
present investigation, TNF-αinduced transcription was found to be initiated exclusively at two …