T cell metabolism in homeostasis and cancer immunity
Highlights•Cell-intrinsic and cell-extrinsic factors influence the metabolic state of T
cells.•Glucose and mitochondrial metabolism regulate antitumor activity of T cells.•Targeting
T reg cell metabolism has therapeutic potential for tumor immunity.•Future perspectives in
immunometabolism and antitumor immunity are discussed.T cells shape immune responses
in cancer, autoimmunity and infection, in which CD4+ T helper (Th) and CD8+ T cells
mediate effector responses that are suppressed by regulatory T (T reg) cells. The balance …
cells.•Glucose and mitochondrial metabolism regulate antitumor activity of T cells.•Targeting
T reg cell metabolism has therapeutic potential for tumor immunity.•Future perspectives in
immunometabolism and antitumor immunity are discussed.T cells shape immune responses
in cancer, autoimmunity and infection, in which CD4+ T helper (Th) and CD8+ T cells
mediate effector responses that are suppressed by regulatory T (T reg) cells. The balance …
Highlights
- Cell-intrinsic and cell-extrinsic factors influence the metabolic state of T cells.
- Glucose and mitochondrial metabolism regulate antitumor activity of T cells.
- Targeting T reg cell metabolism has therapeutic potential for tumor immunity.
- Future perspectives in immunometabolism and antitumor immunity are discussed.
T cells shape immune responses in cancer, autoimmunity and infection, in which CD4+ T helper (Th) and CD8+ T cells mediate effector responses that are suppressed by regulatory T (T reg) cells. The balance between effector T cell and T reg cell function orchestrates immune homeostasis and functional programming, with important contributions to the onset and progression of cancer. Cellular metabolism is dynamically rewired in T cells in response to environmental cues and dictates various aspects of T cell function. In this review, we summarize recent findings on how cellular metabolism modulates effector T cell and T reg cell functional fitness in homeostasis and cancer immunity, and highlight the therapeutic implications of targeting immunometabolic pathways for cancer and other diseases.
Elsevier