Association of rs2075876 polymorphism of AIRE gene with rheumatoid arthritis risk
ZJ Feng, SL Zhang, HF Wen, Y Liang - Human immunology, 2015 - Elsevier
Background Autoimmune regulator (AIRE), a protein encoded by AIRE gene, is a
transcriptional factor primarily expressed in medullary thymic epithelial cells (mTECs). It has
pivotal role in regulation of human immunology. The mutations of AIRE gene or protein level
changes would alter the status of body immunity and therefore onset of diseases. Therefore
we aimed at investigating the association of AIRE gene with the risk of rheumatoid arthritis
(RA). Methods We genotyped 9 SNPs of AIRE gene of recruited 691 patients of rheumatoid …
transcriptional factor primarily expressed in medullary thymic epithelial cells (mTECs). It has
pivotal role in regulation of human immunology. The mutations of AIRE gene or protein level
changes would alter the status of body immunity and therefore onset of diseases. Therefore
we aimed at investigating the association of AIRE gene with the risk of rheumatoid arthritis
(RA). Methods We genotyped 9 SNPs of AIRE gene of recruited 691 patients of rheumatoid …