Expression of AIRE gene in peripheral monocyte/dendritic cell lineage
K Kogawa, S Nagafuchi, H Katsuta, J Kudoh… - Immunology letters, 2002 - Elsevier
The responsible gene for autoimmune polyglandular syndrome type 1, known as
autoimmune regulator (AIRE), was identified by positional cloning. The AIRE gene was
reported to be expressed in the thymus medulla and lymph nodes. However, an expression
of the AIRE gene in peripheral blood cells has not yet been reported. In the present study,
we found that the AIRE gene was restrictively expressed in peripheral CD14-positive
monocytes but not in CD4-positive T cells nor polymorphonuclear cells, as assessed by RT …
autoimmune regulator (AIRE), was identified by positional cloning. The AIRE gene was
reported to be expressed in the thymus medulla and lymph nodes. However, an expression
of the AIRE gene in peripheral blood cells has not yet been reported. In the present study,
we found that the AIRE gene was restrictively expressed in peripheral CD14-positive
monocytes but not in CD4-positive T cells nor polymorphonuclear cells, as assessed by RT …