[HTML][HTML] Modifications to the classical rat aortic ring model to allow vascular degeneration studies
G Blot, TM Sartoris, F Sennlaub, X Guillonneau - STAR protocols, 2021 - Elsevier
G Blot, TM Sartoris, F Sennlaub, X Guillonneau
STAR protocols, 2021•ElsevierThe classical aortic ring model is well suited for deciphering pro-angiogenic processes.
Here, we propose simple modifications of the standard protocol to study various anti-
angiogenic processes from growth arrest to capillary degeneration. Aortic rings are cultured
under basal conditions for 6 days to allow physiological vessel sprouting and then split into
treatment groups to follow capillary growth or degeneration for an additional 2 days.
Here, we propose simple modifications of the standard protocol to study various anti-
angiogenic processes from growth arrest to capillary degeneration. Aortic rings are cultured
under basal conditions for 6 days to allow physiological vessel sprouting and then split into
treatment groups to follow capillary growth or degeneration for an additional 2 days.
Summary
The classical aortic ring model is well suited for deciphering pro-angiogenic processes. Here, we propose simple modifications of the standard protocol to study various anti-angiogenic processes from growth arrest to capillary degeneration. Aortic rings are cultured under basal conditions for 6 days to allow physiological vessel sprouting and then split into treatment groups to follow capillary growth or degeneration for an additional 2 days.
Elsevier
