[HTML][HTML] Unsaturated FAs prevent palmitate-induced LOX-1 induction via inhibition of ER stress in macrophages
J Ishiyama, R Taguchi, Y Akasaka, S Shibata, M Ito… - Journal of lipid …, 2011 - ASBMB
Palmitic acid (PA) upregulates oxidized LDL receptor-1 (LOX-1), a scavenger receptor
responsible for uptake of oxidized LDL (oxLDL), and enhances oxLDL uptake in
macrophages. However, the precise underlying mechanism remains to be elucidated. PA is
known to induce endoplasmic reticulum (ER) stress in various cell types. Therefore, we
investigated whether ER stress is involved in PA-induced LOX-1 upregulation. PA induced
ER stress, as determined by phosphorylation of PERK, eIF2α, and JNK, as well as induction …
responsible for uptake of oxidized LDL (oxLDL), and enhances oxLDL uptake in
macrophages. However, the precise underlying mechanism remains to be elucidated. PA is
known to induce endoplasmic reticulum (ER) stress in various cell types. Therefore, we
investigated whether ER stress is involved in PA-induced LOX-1 upregulation. PA induced
ER stress, as determined by phosphorylation of PERK, eIF2α, and JNK, as well as induction …