[HTML][HTML] G protein–coupled receptors differentially regulate glycosylation and activity of the inwardly rectifying potassium channel Kir7. 1
SJ Carrington, CC Hernandez, DR Swale… - Journal of Biological …, 2018 - ASBMB
Kir7. 1 is an inwardly rectifying potassium channel with important roles in the regulation of
the membrane potential in retinal pigment epithelium, uterine smooth muscle, and
hypothalamic neurons. Regulation of G protein–coupled inwardly rectifying potassium
(GIRK) channels by G protein–coupled receptors (GPCRs) via the G protein βγ subunits has
been well characterized. However, how Kir channels are regulated is incompletely
understood. We report here that Kir7. 1 is also regulated by GPCRs, but through a different …
the membrane potential in retinal pigment epithelium, uterine smooth muscle, and
hypothalamic neurons. Regulation of G protein–coupled inwardly rectifying potassium
(GIRK) channels by G protein–coupled receptors (GPCRs) via the G protein βγ subunits has
been well characterized. However, how Kir channels are regulated is incompletely
understood. We report here that Kir7. 1 is also regulated by GPCRs, but through a different …