Thrombospondin-1 in the trabecular meshwork: localization in normal and glaucomatous eyes, and induction by TGF-β1 and dexamethasone in vitro
C Flügel-Koch, A Ohlmann, R Fuchshofer… - Experimental eye …, 2004 - Elsevier
Transforming growth factor-β2 (TGF-β2) is elevated in the aqueous humor of patients with
primary open-angle glaucoma (POAG), and high levels of TGF-β2 are thought to contribute
to the pathogenesis of POAG. Most TGF-β2 in the eye is present in a latent, inactive form and
the mechanisms of its in vivo activation are unclear. Since thrombospondin-1 (TSP-1) is one
of the most potent in vivo activating molecules of TGF-βs, we investigated the localization
and expression of TSP-1 in the aqueous humor outflow pathways. TSP-1 …
primary open-angle glaucoma (POAG), and high levels of TGF-β2 are thought to contribute
to the pathogenesis of POAG. Most TGF-β2 in the eye is present in a latent, inactive form and
the mechanisms of its in vivo activation are unclear. Since thrombospondin-1 (TSP-1) is one
of the most potent in vivo activating molecules of TGF-βs, we investigated the localization
and expression of TSP-1 in the aqueous humor outflow pathways. TSP-1 …
