Senolytic cocktail dasatinib plus quercetin enhances the antitumor effect of senescence-inducing radiotherapy in a preclinical model of melanoma
Purpose/Objective (s) Although radiation is beneficial in killing tumor cells, it also causes
accumulation of senescent cells in tumors and in the surrounding healthy tissue. Senescent
tumor cells can recover by acquiring a senescence-associated secretory phenotype (SASP),
which leads to undesired tumor cell proliferation. We hypothesize that the clearance of RT-
induced senescence by a senolytic cocktail Dasatinib+ Quercetin (DQ), may enhance the
radio-sensitivity to RT in melanoma. Here, we present data on the effect of DQ and RT on …
accumulation of senescent cells in tumors and in the surrounding healthy tissue. Senescent
tumor cells can recover by acquiring a senescence-associated secretory phenotype (SASP),
which leads to undesired tumor cell proliferation. We hypothesize that the clearance of RT-
induced senescence by a senolytic cocktail Dasatinib+ Quercetin (DQ), may enhance the
radio-sensitivity to RT in melanoma. Here, we present data on the effect of DQ and RT on …
