[HTML][HTML] Multidrug resistance protein 1 (MRP1, ABCC1), a “multitasking” ATP-binding cassette (ABC) transporter
SPC Cole - Journal of Biological Chemistry, 2014 - ASBMB
The multidrug resistance protein 1 (MRP1) encoded by ABCC1 was originally discovered as
a cause of multidrug resistance in tumor cells. However, it is now clear that MRP1 serves a
broader role than simply mediating the ATP-dependent efflux of drugs from cells. The
antioxidant GSH and the pro-inflammatory cysteinyl leukotriene C 4 have been identified as
key physiological organic anions effluxed by MRP1, and an ever growing body of evidence
indicates that additional lipid-derived mediators are also substrates of this transporter. As …
a cause of multidrug resistance in tumor cells. However, it is now clear that MRP1 serves a
broader role than simply mediating the ATP-dependent efflux of drugs from cells. The
antioxidant GSH and the pro-inflammatory cysteinyl leukotriene C 4 have been identified as
key physiological organic anions effluxed by MRP1, and an ever growing body of evidence
indicates that additional lipid-derived mediators are also substrates of this transporter. As …
