[HTML][HTML] FoxF1 and FoxL1 link hedgehog signaling and the control of epithelial proliferation in the developing stomach and intestine
BB Madison, LB McKenna, D Dolson, DJ Epstein… - Journal of biological …, 2009 - ASBMB
The hedgehog (Hh) signaling pathway is a key component of cross-talk during vertebrate
gut development, involving endodermally secreted Sonic (Shh) and Indian hedgehog (Ihh)
proteins that directly signal to adjacent mesoderm. Here we show that the closely linked
mesenchymal forkhead transcription factors Foxf1 and Foxl1 are part of this signaling
cascade. Analysis of conserved non-coding sequences surrounding Foxf1 and Foxl1
identified seven Gli binding sites, with two sites near Foxl1 being identical among …
gut development, involving endodermally secreted Sonic (Shh) and Indian hedgehog (Ihh)
proteins that directly signal to adjacent mesoderm. Here we show that the closely linked
mesenchymal forkhead transcription factors Foxf1 and Foxl1 are part of this signaling
cascade. Analysis of conserved non-coding sequences surrounding Foxf1 and Foxl1
identified seven Gli binding sites, with two sites near Foxl1 being identical among …