A role for eosinophils in airway remodelling in asthma
AB Kay, S Phipps, DS Robinson - Trends in immunology, 2004 - cell.com
AB Kay, S Phipps, DS Robinson
Trends in immunology, 2004•cell.comOver the years, the role of the eosinophil in asthma and allergic processes has been
disputed. Recent human experiments using a humanised monoclonal antibody to interleukin-
5 (IL-5), and animal studies involving specific IL-5 gene deletion, indicates that eosinophils
might control downstream repair and remodelling processes. Eosinophils are a rich source
of fibrogenic factors, particularly transforming growth factor-β (TGF-β), the latent form of
which is activated by epithelial-cell expression of the intergin α v β 6. The emerging role for …
disputed. Recent human experiments using a humanised monoclonal antibody to interleukin-
5 (IL-5), and animal studies involving specific IL-5 gene deletion, indicates that eosinophils
might control downstream repair and remodelling processes. Eosinophils are a rich source
of fibrogenic factors, particularly transforming growth factor-β (TGF-β), the latent form of
which is activated by epithelial-cell expression of the intergin α v β 6. The emerging role for …
Over the years, the role of the eosinophil in asthma and allergic processes has been disputed. Recent human experiments using a humanised monoclonal antibody to interleukin-5 (IL-5), and animal studies involving specific IL-5 gene deletion, indicates that eosinophils might control downstream repair and remodelling processes. Eosinophils are a rich source of fibrogenic factors, particularly transforming growth factor-β (TGF-β), the latent form of which is activated by epithelial-cell expression of the intergin αvβ6. The emerging role for the eosinophil in airway remodelling might be important in future anti-asthma strategies. However, more effective eosinophil-depleting agents than anti-IL-5 are required before the definitive role of this cell type in asthma airway pathophysiology can be established.
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