[HTML][HTML] Mutational analysis of Norrin-Frizzled4 recognition
PM Smallwood, J Williams, Q Xu, DJ Leahy… - Journal of Biological …, 2007 - ASBMB
Norrin and Frizzled4 (Fz4) function as a ligand-receptor pair to control vascular development
in the retina and inner ear. In mice and humans, mutations in either of the corresponding
genes lead to defects in vascular development. The present work is aimed at defining the
sequence determinants of binding specificity between Norrin and the Fz4 amino-terminal
ligand-binding domain (the" cysteine-rich domain"(CRD)). The principal conclusions are as
follows: 1) Norrin binds to the Fz4 CRD and does not detectably bind to the 14 other …
in the retina and inner ear. In mice and humans, mutations in either of the corresponding
genes lead to defects in vascular development. The present work is aimed at defining the
sequence determinants of binding specificity between Norrin and the Fz4 amino-terminal
ligand-binding domain (the" cysteine-rich domain"(CRD)). The principal conclusions are as
follows: 1) Norrin binds to the Fz4 CRD and does not detectably bind to the 14 other …
