[HTML][HTML] Profiling of VEGFs and VEGFRs as prognostic factors in soft tissue sarcoma: VEGFR-3 is an independent predictor of poor prognosis
TK Kilvaer, A Valkov, S Sorbye, E Smeland… - PloS one, 2010 - journals.plos.org
TK Kilvaer, A Valkov, S Sorbye, E Smeland, RM Bremnes, LT Busund, T Donnem
PloS one, 2010•journals.plos.orgBackground In non-gastrointestinal stromal tumor soft tissue sarcoma (non-GIST STS)
optimal treatment is surgery with wide resection margins. Vascular endothelial growth
factors (VEGFs) and receptors (VEGFRs) are known to be key players in the initiation of
angiogenesis and lymphangiogenesis. This study investigates the prognostic impact of
VEGFs and VEGFRs in non-GIST STS with wide and non-wide resection margins. Methods
Tumor samples from 249 patients with non-GIST STS were obtained and tissue microarrays …
optimal treatment is surgery with wide resection margins. Vascular endothelial growth
factors (VEGFs) and receptors (VEGFRs) are known to be key players in the initiation of
angiogenesis and lymphangiogenesis. This study investigates the prognostic impact of
VEGFs and VEGFRs in non-GIST STS with wide and non-wide resection margins. Methods
Tumor samples from 249 patients with non-GIST STS were obtained and tissue microarrays …
Background
In non-gastrointestinal stromal tumor soft tissue sarcoma (non-GIST STS) optimal treatment is surgery with wide resection margins. Vascular endothelial growth factors (VEGFs) and receptors (VEGFRs) are known to be key players in the initiation of angiogenesis and lymphangiogenesis. This study investigates the prognostic impact of VEGFs and VEGFRs in non-GIST STS with wide and non-wide resection margins.
Methods
Tumor samples from 249 patients with non-GIST STS were obtained and tissue microarrays were constructed for each specimen. Immunohistochemistry was used to evaluate the expressions of VEGF-A, -C and -D and VEGFR-1, -2 and -3.
Results
In the univariate analyses, VEGF-A (P = 0.040) in the total material, and VEGF-A (P = 0.018), VEGF-C (P = 0.025) and VEGFR-3 (P = 0.027) in the subgroup with wide resection margins, were significant negative prognostic indicators of disease-specific survival (DSS). In the multivariate analysis, high expression of VEGFR-3 (P = 0.042, HR = 1.907, 95% CI 1.024-3.549) was an independent significant negative prognostic marker for DSS among patients with wide resection margins.
Conclusion
VEGFR-3 is a strong and independent negative prognostic marker for non-GIST STSs with wide resection margins.
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