Angiogenesis in follicular tumors of the thyroid
K Segal, T Shpitzer, M Feinmesser… - Journal of surgical …, 1996 - Wiley Online Library
K Segal, T Shpitzer, M Feinmesser, Y Stern, R Feinmesser
Journal of surgical oncology, 1996•Wiley Online LibraryBackground Experimental evidence suggests that tumor growth beyond a certain size and
tumor ability to metastasize depend on the degree to which the tumor can stimulate an
angiogenic response. Methods Fifteen thyroid specimens of microinvasive follicular
carcinoma were examined for vascularization by immunohistochemical stain with antifactor
VIII antibodies and compared with an equal number of follicular adenomas. Results
Pleomorphic areas in the histological specimens of follicular carcinomas had a higher rate of …
tumor ability to metastasize depend on the degree to which the tumor can stimulate an
angiogenic response. Methods Fifteen thyroid specimens of microinvasive follicular
carcinoma were examined for vascularization by immunohistochemical stain with antifactor
VIII antibodies and compared with an equal number of follicular adenomas. Results
Pleomorphic areas in the histological specimens of follicular carcinomas had a higher rate of …
Background
Experimental evidence suggests that tumor growth beyond a certain size and tumor ability to metastasize depend on the degree to which the tumor can stimulate an angiogenic response.
Methods
Fifteen thyroid specimens of microinvasive follicular carcinoma were examined for vascularization by immunohistochemical stain with antifactor VIII antibodies and compared with an equal number of follicular adenomas.
Results
Pleomorphic areas in the histological specimens of follicular carcinomas had a higher rate of vascularization as did areas of tumor adjacent to or penetrating the capsule. These features were not noted in follicular adenomas.
Conclusions
Our findings indicate that vascularity may play a role in extracapsular extension and tumor aggression in follicular thyroid carcinomas. © 1996 Wiley‐Liss, Inc.
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