Immunological characterization of latent tuberculosis infection in a low endemic country
RA de Paus, KE van Meijgaarden, C Prins… - Tuberculosis, 2017 - Elsevier
The diagnosis of a latent tuberculosis infection (LTBI) is based on detection of immunity
against Mycobacterium tuberculosis (Mtb). The tuberculin skin test (TST), the Quantiferon
(QFT) and a prolonged lymphocyte stimulation test using either ESAT-6/CFP-10 (LST-EC) or
PPD (LST-PPD) were evaluated in a cohort of 495 individuals, suspected to have LTBI, in a
low endemic country. While the TST and LST-PPD were both positive in the majority (75%)
of individuals, only one third responded in the LST-EC and in the QFT. The choice for LTBI …
against Mycobacterium tuberculosis (Mtb). The tuberculin skin test (TST), the Quantiferon
(QFT) and a prolonged lymphocyte stimulation test using either ESAT-6/CFP-10 (LST-EC) or
PPD (LST-PPD) were evaluated in a cohort of 495 individuals, suspected to have LTBI, in a
low endemic country. While the TST and LST-PPD were both positive in the majority (75%)
of individuals, only one third responded in the LST-EC and in the QFT. The choice for LTBI …
