Histologic analysis of chronic rejection in small bowel transplantation: mucosal and vascular alterations
BJ Swanson, GA Talmon, JW Wisecarver… - …, 2013 - journals.lww.com
BJ Swanson, GA Talmon, JW Wisecarver, WJ Grant, SJ Radio
Transplantation, 2013•journals.lww.comBackground Chronic rejection is a significant barrier to small bowel allograft survival.
Although chronic rejection primarily involves vessels of the submucosa, serosa, and
mesentery, some mucosal alterations have been suggested to be correlative. Methods We
retrospectively investigated explanted small bowel allografts for clinical characteristics and
histological alterations in the mucosa, submucosa, and serosa. Results Crypt epithelial
mucin loss, submucosal fibrosis, and length of time to explant were all statistically …
Although chronic rejection primarily involves vessels of the submucosa, serosa, and
mesentery, some mucosal alterations have been suggested to be correlative. Methods We
retrospectively investigated explanted small bowel allografts for clinical characteristics and
histological alterations in the mucosa, submucosa, and serosa. Results Crypt epithelial
mucin loss, submucosal fibrosis, and length of time to explant were all statistically …
Abstract
Background
Chronic rejection is a significant barrier to small bowel allograft survival. Although chronic rejection primarily involves vessels of the submucosa, serosa, and mesentery, some mucosal alterations have been suggested to be correlative.
Methods
We retrospectively investigated explanted small bowel allografts for clinical characteristics and histological alterations in the mucosa, submucosa, and serosa.
Results
Crypt epithelial mucin loss, submucosal fibrosis, and length of time to explant were all statistically associated with chronic rejection. Medium-sized and large-sized vessels of the serosa and mesentery preferentially demonstrated histologic changes of chronic rejection.
Conclusion
These results further define chronic vascular rejection and the relationship between the mucosal changes and chronic rejection.
Lippincott Williams & Wilkins