Infancy weight gain predicts childhood body fat and age at menarche in girls
KK Ong, P Emmett, K Northstone… - The Journal of …, 2009 - academic.oup.com
The Journal of Clinical Endocrinology & Metabolism, 2009•academic.oup.com
Context: Rapid postnatal weight gain has been associated with subsequent increased
childhood adiposity. However, the contribution of rapid weight gain during specific infancy
periods is not clear. Objective: We aimed to determine which periods of infancy weight gain
are related to childhood adiposity and also to age at menarche in UK girls. Design, Setting,
and Participants: A total of 2715 girls from a prospective UK birth cohort study participated in
the study. Main Outcome Measures: Routinely measured weights and lengths at ages 2, 9 …
childhood adiposity. However, the contribution of rapid weight gain during specific infancy
periods is not clear. Objective: We aimed to determine which periods of infancy weight gain
are related to childhood adiposity and also to age at menarche in UK girls. Design, Setting,
and Participants: A total of 2715 girls from a prospective UK birth cohort study participated in
the study. Main Outcome Measures: Routinely measured weights and lengths at ages 2, 9 …
Abstract
Context: Rapid postnatal weight gain has been associated with subsequent increased childhood adiposity. However, the contribution of rapid weight gain during specific infancy periods is not clear.
Objective: We aimed to determine which periods of infancy weight gain are related to childhood adiposity and also to age at menarche in UK girls.
Design, Setting, and Participants: A total of 2715 girls from a prospective UK birth cohort study participated in the study.
Main Outcome Measures: Routinely measured weights and lengths at ages 2, 9, and 19 months were extracted from the local child health computer database. Body composition was assessed by dual-energy x-ray absorptiometry at age 10 yr, and age at menarche was assessed by questionnaire (categorized into three groups: <12.0, 12.0–13.0, and >13.0 yr).
Results: Faster early infancy weight gain between 0 and 2 months and also 2 to 9 months were associated with increased body fat mass relative to lean mass at age 10 yr and also with earlier age at menarche. Each +1 unit gain in weight sd score between 0 and 9 months was associated with an odds ratio (95% confidence interval) = 1.48 (1.27–1.60) for overweight (body mass index > 85th centile) at 10 yr, and 1.34 (1.21–1.49) for menarche at less than 12 yr. In contrast, subsequent weight gain between 9 and 19 months was not associated with later adiposity or age at menarche.
Conclusions: In developed settings, rapid weight gain during the first 9 months of life is a risk factor for both increased childhood adiposity and early menarche in girls.
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