[HTML][HTML] Similarity in genetic alterations between paired well-differentiated and dedifferentiated components of dedifferentiated liposarcoma
AE Horvai, S DeVries, R Roy, RJ O'donnell… - Modern Pathology, 2009 - Elsevier
Liposarcoma represents a unique model insofar as some well-differentiated liposarcomas
progress to non-lipogenic, so-called'dedifferentiated,'forms. The well-differentiated and
dedifferentiated family of liposarcomas demonstrates amplification of the chromosome
subregion 12q13–q15 with resultant amplification of the MDM2 and CDK4 genes. However,
the specific genetic changes that distinguish between well-differentiated and
dedifferentiated liposarcomas are less well understood. To study the genetic changes in …
progress to non-lipogenic, so-called'dedifferentiated,'forms. The well-differentiated and
dedifferentiated family of liposarcomas demonstrates amplification of the chromosome
subregion 12q13–q15 with resultant amplification of the MDM2 and CDK4 genes. However,
the specific genetic changes that distinguish between well-differentiated and
dedifferentiated liposarcomas are less well understood. To study the genetic changes in …
