Protein tyrosine phosphatases: structure, function, and implication in human disease
L Tautz, DA Critton, S Grotegut - Phosphatase Modulators, 2013 - Springer
L Tautz, DA Critton, S Grotegut
Phosphatase Modulators, 2013•SpringerProtein tyrosine phosphorylation is a key regulatory mechanism in eukaryotic cell
physiology. Aberrant expression or function of protein tyrosine kinases and protein tyrosine
phosphatases can lead to serious human diseases, including cancer, diabetes, as well as
cardiovascular, infectious, autoimmune, and neuropsychiatric disorders. Here, we give an
overview of the protein tyrosine phosphatase superfamily with its over 100 members in
humans. We review their structure, function, and implications in human diseases, and …
physiology. Aberrant expression or function of protein tyrosine kinases and protein tyrosine
phosphatases can lead to serious human diseases, including cancer, diabetes, as well as
cardiovascular, infectious, autoimmune, and neuropsychiatric disorders. Here, we give an
overview of the protein tyrosine phosphatase superfamily with its over 100 members in
humans. We review their structure, function, and implications in human diseases, and …
Abstract
Protein tyrosine phosphorylation is a key regulatory mechanism in eukaryotic cell physiology. Aberrant expression or function of protein tyrosine kinases and protein tyrosine phosphatases can lead to serious human diseases, including cancer, diabetes, as well as cardiovascular, infectious, autoimmune, and neuropsychiatric disorders. Here, we give an overview of the protein tyrosine phosphatase superfamily with its over 100 members in humans. We review their structure, function, and implications in human diseases, and discuss their potential as novel drug targets, as well as current challenges and possible solutions to developing therapeutics based on these enzymes.
Springer
