[HTML][HTML] Protein-tyrosine phosphatase 1B (PTP1B) is a novel regulator of central brain-derived neurotrophic factor and tropomyosin receptor kinase B (TrkB) signaling
Neuronal protein-tyrosine phosphatase 1B (PTP1B) deficiency in mice results in enhanced
leptin signaling and protection from diet-induced obesity; however, whether additional
signaling pathways in the brain contribute to the metabolic effects of PTP1B deficiency
remains unclear. Here, we show that the tropomyosin receptor kinase B (TrkB) receptor is a
direct PTP1B substrate and implicate PTP1B in the regulation of the central brain-derived
neurotrophic factor (BDNF) signaling. PTP1B interacts with activated TrkB receptor in mouse …
leptin signaling and protection from diet-induced obesity; however, whether additional
signaling pathways in the brain contribute to the metabolic effects of PTP1B deficiency
remains unclear. Here, we show that the tropomyosin receptor kinase B (TrkB) receptor is a
direct PTP1B substrate and implicate PTP1B in the regulation of the central brain-derived
neurotrophic factor (BDNF) signaling. PTP1B interacts with activated TrkB receptor in mouse …
