The reciprocal role of Egr-1 and Sp family proteins in regulation of the PTP1B promoter in response to the p210 Bcr-Abl oncoprotein-tyrosine kinase
T Fukada, NK Tonks - Journal of Biological Chemistry, 2001 - ASBMB
Protein-tyrosine phosphatase 1B (PTP1B) is an important regulator of protein-tyrosine
kinase-dependent signaling pathways. Changes in expression and activity of PTP1B have
been associated with various human diseases; however, the mechanisms by which PTP1B
expression is regulated have yet to be characterized. Previously, we have shown that the
expression of PTP1B is enhanced by p210 Bcr-Abl and that PTP1B is a specific antagonist
of transformation induced by this oncoprotein protein-tyrosine kinase. Here we have …
kinase-dependent signaling pathways. Changes in expression and activity of PTP1B have
been associated with various human diseases; however, the mechanisms by which PTP1B
expression is regulated have yet to be characterized. Previously, we have shown that the
expression of PTP1B is enhanced by p210 Bcr-Abl and that PTP1B is a specific antagonist
of transformation induced by this oncoprotein protein-tyrosine kinase. Here we have …
