Extensive in vitro studies have shown that multipotent mesenchymal stromal cells (MSC) can
exert profound immunosuppressive effects via modulation of both cellular and innate
immune pathways. Their ability to be readily isolated from a number of tissues and
expanded ex vivo makes them attractive candidates for systemic immunosuppressive
therapy. In this article, we will review recent experimental data on the mechanisms by which
MSC inhibit the alloproliferative response and the clinical relevance for their potential use in …