[HTML][HTML] Weekly oral alendronate in mevalonate kinase deficiency
L Cantarini, A Vitale, F Magnotti, OM Lucherini… - Orphanet Journal of …, 2013 - Springer
Orphanet Journal of Rare Diseases, 2013•Springer
Background Mevalonate kinase deficiency (MKD) is caused by mutations in the MVK gene,
encoding the second enzyme of mevalonate pathway, which results in subsequent shortage
of downstream compounds, and starts in childhood with febrile attacks, skin, joint, and
gastrointestinal symptoms, sometimes induced by vaccinations. Methods For a history of
early-onset corticosteroid-induced reduction of bone mineral density in a 14-year-old boy
with MKD, who also had presented three bone fractures, we administered weekly oral …
encoding the second enzyme of mevalonate pathway, which results in subsequent shortage
of downstream compounds, and starts in childhood with febrile attacks, skin, joint, and
gastrointestinal symptoms, sometimes induced by vaccinations. Methods For a history of
early-onset corticosteroid-induced reduction of bone mineral density in a 14-year-old boy
with MKD, who also had presented three bone fractures, we administered weekly oral …
Background
Mevalonate kinase deficiency (MKD) is caused by mutations in the MVK gene, encoding the second enzyme of mevalonate pathway, which results in subsequent shortage of downstream compounds, and starts in childhood with febrile attacks, skin, joint, and gastrointestinal symptoms, sometimes induced by vaccinations.
Methods
For a history of early-onset corticosteroid-induced reduction of bone mineral density in a 14-year-old boy with MKD, who also had presented three bone fractures, we administered weekly oral alendronate, a drug widely used in the management of osteoporosis and other high bone turnover diseases, which blocks mevalonate and halts the prenylation process.
Results
All of the patient’s MKD clinical and laboratory abnormalities were resolved after starting alendronate treatment.
Conclusions
This observation appears enigmatic, since alendronate should reinforce the metabolic block characterizing MKD, but is crucial because of the ultimate improvement shown by this patient. The anti-inflammatory properties of bisphosphonates are a new question for debate among physicians across various specialties, and requires further biochemical and clinical investigation.
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