[HTML][HTML] Microbial isoprenoid biosynthesis and human γδ T cell activation
M Eberl, M Hintz, A Reichenberg, AK Kollas, J Wiesner… - FEBS letters, 2003 - Elsevier
M Eberl, M Hintz, A Reichenberg, AK Kollas, J Wiesner, H Jomaa
FEBS letters, 2003•ElsevierHuman Vγ9/Vδ2 T cells play a crucial role in the immune response to microbial pathogens,
yet their unconventional reactivity towards non-peptide antigens has been enigmatic until
recently. The break-through in identification of the specific activator was only possible due to
recent success in a seemingly remote field: the elucidation of the reaction steps of the newly
discovered 2-C-methyl-D-erythritol-4-phosphate (MEP) pathway of isoprenoid biosynthesis
that is utilised by many pathogenic bacteria. Unexpectedly, the intermediate of the MEP …
yet their unconventional reactivity towards non-peptide antigens has been enigmatic until
recently. The break-through in identification of the specific activator was only possible due to
recent success in a seemingly remote field: the elucidation of the reaction steps of the newly
discovered 2-C-methyl-D-erythritol-4-phosphate (MEP) pathway of isoprenoid biosynthesis
that is utilised by many pathogenic bacteria. Unexpectedly, the intermediate of the MEP …
Human Vγ9/Vδ2 T cells play a crucial role in the immune response to microbial pathogens, yet their unconventional reactivity towards non-peptide antigens has been enigmatic until recently. The break-through in identification of the specific activator was only possible due to recent success in a seemingly remote field: the elucidation of the reaction steps of the newly discovered 2-C-methyl-D-erythritol-4-phosphate (MEP) pathway of isoprenoid biosynthesis that is utilised by many pathogenic bacteria. Unexpectedly, the intermediate of the MEP pathway, (E)-4-hydroxy-3-methyl-but-2-enyl-pyrophosphate) (HMB-PP), turned out to be by far the most potent Vγ9/Vδ2 T cell activator known, with an EC50 of 0.1 nM.
Elsevier