Objective: The efficacy of naltrexone (Revia, Vivitrol) for the treatment of alcohol
dependence exhibits a high degree of heterogeneity. The aim of the current study was to
evaluate the extent to which variability in patient adherence to treatment contributed to the
range of clinical responses observed during naltrexone treatment. Method: A systematic
review was conducted of efficacy trials of naltrexone for the treatment of alcohol dependence
to evaluate the level of adherence monitoring. Results: Of 49 identified trials, 22 (49%) met …