Signal transducer and activator of transcription 3 (Stat3) is a latent cytoplasmic protein that
conveys signals to the nucleus upon stimulation with IL-6, EGF, and many other
cytokines/growth factors, leading to transcriptional activation of the downstream genes. It has
been well defined that Stat3 plays critical roles in biological activities including cell
proliferation, migration, survival, and oncogenesis. The in vivo role for Stat3 in the skin was
elucidated using keratinocyte-specific Stat3 gene knockout mice, referred to as Stat3 …