Epidermal growth factor receptor: mechanisms of activation and signalling
RN Jorissen, F Walker, N Pouliot, TPJ Garrett… - The EGF receptor …, 2003 - Elsevier
Publisher Summary This chapter discusses the structure and function of the epidermal
growth factor (EGF) receptor (EGFR), from ligand binding to the initiation of intracellular
signaling pathways that lead to changes in the biochemical state of the cell. The epidermal
growth factor receptor (EGFR) regulates the intracellular effects of ligands such as EGF and
transforming growth factor-α (TGFα). The EGFR kinase catalyzes the transfer of γ-phosphate
of bound ATP to the tyrosine residues of exogenous substrates, and the C-terminal domains …
growth factor (EGF) receptor (EGFR), from ligand binding to the initiation of intracellular
signaling pathways that lead to changes in the biochemical state of the cell. The epidermal
growth factor receptor (EGFR) regulates the intracellular effects of ligands such as EGF and
transforming growth factor-α (TGFα). The EGFR kinase catalyzes the transfer of γ-phosphate
of bound ATP to the tyrosine residues of exogenous substrates, and the C-terminal domains …
