Chromatin compaction by human MeCP2: assembly of novel secondary chromatin structures in the absence of DNA methylation
PT Georgel, RA Horowitz-Scherer, N Adkins… - Journal of Biological …, 2003 - ASBMB
MeCP2 is a transcriptional repressor that contains an N-terminal methylated DNA-binding
domain, a central transcription regulation domain, and a C-terminal domain of unknown
function. Whereas current models of MeCP2 function evoke localized recruitment of histone
deacetylases to specific methylated regions of the genome, it is unclear whether MeCP2
requires DNA methylation to bind to chromatin or whether MeCP2 binding influences
chromatin structure in the absence of other proteins. To address these issues, we have …
domain, a central transcription regulation domain, and a C-terminal domain of unknown
function. Whereas current models of MeCP2 function evoke localized recruitment of histone
deacetylases to specific methylated regions of the genome, it is unclear whether MeCP2
requires DNA methylation to bind to chromatin or whether MeCP2 binding influences
chromatin structure in the absence of other proteins. To address these issues, we have …
