[HTML][HTML] Human HDAC7 harbors a class IIa histone deacetylase-specific zinc binding motif and cryptic deacetylase activity
A Schuetz, J Min, A Allali-Hassani, M Schapira… - Journal of Biological …, 2008 - ASBMB
Histone deacetylases (HDACs) are protein deacetylases that play a role in repression of
gene transcription and are emerging targets in cancer therapy. Here, we characterize the
structure and enzymatic activity of the catalytic domain of human HDAC7 (cdHDAC7).
Although HDAC7 normally exists as part of a multiprotein complex, we show that cdHDAC7
has a low level of deacetylase activity which can be inhibited by known HDAC inhibitors.
The crystal structures of human cdHDAC7 and its complexes with two hydroxamate …
gene transcription and are emerging targets in cancer therapy. Here, we characterize the
structure and enzymatic activity of the catalytic domain of human HDAC7 (cdHDAC7).
Although HDAC7 normally exists as part of a multiprotein complex, we show that cdHDAC7
has a low level of deacetylase activity which can be inhibited by known HDAC inhibitors.
The crystal structures of human cdHDAC7 and its complexes with two hydroxamate …