[HTML][HTML] Post-activation turn-off of NF-κB-dependent transcription is regulated by acetylation of p65
R Kiernan, V Brès, RWM Ng, MP Coudart… - Journal of Biological …, 2003 - ASBMB
NF-κB represents a family of eukaryotic transcription factors participating in the regulation of
various cellular genes involved in the immediate early processes of immune, acute-phase,
and inflammatory responses. Cellular localization and consequently the transcriptional
activity of NF-κB is tightly regulated by its partner IκBα. Here, we show that the p65 subunit of
NF-κB is acetylated by both p300 and PCAF on lysines 122 and 123. Both HDAC2 and
HDAC3 interact with p65, although only HDAC3 was able to deacetylate p65. Acetylation of …
various cellular genes involved in the immediate early processes of immune, acute-phase,
and inflammatory responses. Cellular localization and consequently the transcriptional
activity of NF-κB is tightly regulated by its partner IκBα. Here, we show that the p65 subunit of
NF-κB is acetylated by both p300 and PCAF on lysines 122 and 123. Both HDAC2 and
HDAC3 interact with p65, although only HDAC3 was able to deacetylate p65. Acetylation of …