[HTML][HTML] Receptor-mediated regulation of tomosyn-syntaxin 1A interactions in bovine adrenal chromaffin cells
SE Gladycheva, AD Lam, J Liu… - Journal of Biological …, 2007 - ASBMB
Tomosyn, a soluble R-SNARE protein identified as a binding partner of the Q-SNARE
syntaxin 1A, is thought to be critical in setting the level of fusion-competent SNARE
complexes for neurosecretion. To date, there has been no direct evaluation of the dynamics
in which tomosyn transits through tomosyn-SNARE complexes or of the extent to which
tomosyn-SNARE complexes are regulated by secretory demand. Here, we employed
biochemical and optical approaches to characterize the dynamic properties of tomosyn …
syntaxin 1A, is thought to be critical in setting the level of fusion-competent SNARE
complexes for neurosecretion. To date, there has been no direct evaluation of the dynamics
in which tomosyn transits through tomosyn-SNARE complexes or of the extent to which
tomosyn-SNARE complexes are regulated by secretory demand. Here, we employed
biochemical and optical approaches to characterize the dynamic properties of tomosyn …