[HTML][HTML] Structural Basis for the Inhibitory Role of Tomosyn in Exocytosis*♦
AV Pobbati, A Razeto, M Böddener, S Becker… - Journal of Biological …, 2004 - ASBMB
Upon Ca 2+ influx synaptic vesicles fuse with the plasma membrane and release their
neurotransmitter cargo into the synaptic cleft. Key players during this process are the Q-
SNAREs syntaxin 1a and SNAP-25 and the R-SNARE synaptobrevin 2. It is thought that
these membrane proteins gradually assemble into a tight trans-SNARE complex between
vesicular and plasma membrane, ultimately leading to membrane fusion. Tomosyn is a
soluble protein of 130 kDa that contains a COOH-terminal R-SNARE motif but lacks a …
neurotransmitter cargo into the synaptic cleft. Key players during this process are the Q-
SNAREs syntaxin 1a and SNAP-25 and the R-SNARE synaptobrevin 2. It is thought that
these membrane proteins gradually assemble into a tight trans-SNARE complex between
vesicular and plasma membrane, ultimately leading to membrane fusion. Tomosyn is a
soluble protein of 130 kDa that contains a COOH-terminal R-SNARE motif but lacks a …