[HTML][HTML] Regulation of Weibel-Palade body exocytosis by α-synuclein in endothelial cells
KS Kim, JY Park, I Jou, SM Park - Journal of biological chemistry, 2010 - ASBMB
α-Synuclein is a small presynaptic protein implicated in the pathogenesis of Parkinson
disease. Nevertheless, its physiological roles and mechanisms remain incompletely
understood. α-Synuclein is not only expressed in neurons but also in the vascular
endothelium, which contains intracellular granules called Weibel-Palade bodies (WPBs) that
contain a number of chemokines, adhesive molecules, and inflammatory cytokines. This
study explored whether the exocytosis of WPB is regulated by α-synuclein. Phorbol 12 …
disease. Nevertheless, its physiological roles and mechanisms remain incompletely
understood. α-Synuclein is not only expressed in neurons but also in the vascular
endothelium, which contains intracellular granules called Weibel-Palade bodies (WPBs) that
contain a number of chemokines, adhesive molecules, and inflammatory cytokines. This
study explored whether the exocytosis of WPB is regulated by α-synuclein. Phorbol 12 …