[HTML][HTML] The Epac-Rap1 signaling pathway controls cAMP-mediated exocytosis of Weibel-Palade bodies in endothelial cells
KWEM van Hooren, EL van Agtmaal… - Journal of Biological …, 2012 - ASBMB
Endothelial cells contain specialized storage organelles called Weibel-Palade bodies
(WPBs) that release their content into the vascular lumen in response to specific agonists
that raise intracellular Ca 2+ or cAMP. We have previously shown that cAMP-mediated WPB
release is dependent on protein kinase A (PKA) and involves activation of the small GTPase
RalA. Here, we have investigated a possible role for another PKA-independent cAMP-
mediated signaling pathway in the regulation of WPB exocytosis, namely the guanine …
(WPBs) that release their content into the vascular lumen in response to specific agonists
that raise intracellular Ca 2+ or cAMP. We have previously shown that cAMP-mediated WPB
release is dependent on protein kinase A (PKA) and involves activation of the small GTPase
RalA. Here, we have investigated a possible role for another PKA-independent cAMP-
mediated signaling pathway in the regulation of WPB exocytosis, namely the guanine …