RAGE binds C1q and enhances C1q-mediated phagocytosis
RAGE, the multiligand receptor of the immunoglobulin superfamily of cell surface molecules,
is implicated in innate and adaptive immunity. Complement component C1q serves roles in
complement activation and antibody-independent opsonization. Using soluble forms of
RAGE (sRAGE) and RAGE-expressing cells, we determined that RAGE is a native C1q
globular domain receptor. Direct C1q–sRAGE interaction was demonstrated with surface
plasmon resonance (SPR), with minimum Kd 5.6 μM, and stronger binding affinity seen in …
is implicated in innate and adaptive immunity. Complement component C1q serves roles in
complement activation and antibody-independent opsonization. Using soluble forms of
RAGE (sRAGE) and RAGE-expressing cells, we determined that RAGE is a native C1q
globular domain receptor. Direct C1q–sRAGE interaction was demonstrated with surface
plasmon resonance (SPR), with minimum Kd 5.6 μM, and stronger binding affinity seen in …