The biological activities of spermatogonial stem cells (SSCs) are the foundation for
spermatogenesis and thus sustained male fertility. Therefore, understanding the
mechanisms governing their ability to both self‐renew and differentiate is essential.
Moreover, because SSCs are the only adult stem cell to contribute genetic information to the
next generation, they are an excellent target for genetic modification. In this chapter, we
discuss two important approaches to investigate SSCs and their cognate niche …