Molecular properties of fibrin-based matrices for promotion of angiogenesis in vitro
H Hall, T Baechi, JA Hubbell - Microvascular research, 2001 - Elsevier
The molecular properties of fibrin-based matrices, such as fibrillar structure and covalent
modifications with adhesion domains, influence the angiogenic behavior of human umbilical
vein endothelial cells (HUVECs) in vitro. The fibrillar structure of fibrin-based matrices was
influenced by pH but not by covalent incorporation of exogenous adhesion domains. Native
fibrin-based matrices polymerized at pH 10 formed organized and longitudinally oriented
fibrin fibrils, which provided a good angiogenic substrate for endothelial cells. Furthermore …
modifications with adhesion domains, influence the angiogenic behavior of human umbilical
vein endothelial cells (HUVECs) in vitro. The fibrillar structure of fibrin-based matrices was
influenced by pH but not by covalent incorporation of exogenous adhesion domains. Native
fibrin-based matrices polymerized at pH 10 formed organized and longitudinally oriented
fibrin fibrils, which provided a good angiogenic substrate for endothelial cells. Furthermore …