As it becomes evident that single nucleotide polymorphisms (SNPs) in humans can create
metabolic inefficiencies, it is reasonable to ask if such SNPs influence dietary requirements.
Epidemiologic studies that examine SNPs relative to risks for diseases are common, but
there are few examples of clinically sized nutrition studies that examine how SNPs influence
metabolism. Studies on how SNPs influence the dietary requirement for choline provide a
model for how we might begin examining the effects of SNPs on nutritional phenotypes …