Tacrolimus and TGF-β act synergistically on the generation of Langerhans cells
B Kwiek, WM Peng, JP Allam, A Langner… - Journal of allergy and …, 2008 - Elsevier
BACKGROUND: The proportion of dendritic cell subpopulations in the skin is important for
the severity of atopic dermatitis because topical treatment with tacrolimus leads to rapid
depletion of inflammatory dendritic epidermal cells, whereas Langerhans cells (LCs)
predominate in cured sites. OBJECTIVES: The effects of tacrolimus and TGF-β1 on LC
differentiation and the idea of tacrolimus skewing the differentiation of epidermal precursors
to LCs were evaluated. METHODS: The presence of LC markers, MHC, and costimulatory …
the severity of atopic dermatitis because topical treatment with tacrolimus leads to rapid
depletion of inflammatory dendritic epidermal cells, whereas Langerhans cells (LCs)
predominate in cured sites. OBJECTIVES: The effects of tacrolimus and TGF-β1 on LC
differentiation and the idea of tacrolimus skewing the differentiation of epidermal precursors
to LCs were evaluated. METHODS: The presence of LC markers, MHC, and costimulatory …