Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes
H Land, LF Parada, RA Weinberg - Nature, 1983 - nature.com
H Land, LF Parada, RA Weinberg
Nature, 1983•nature.comTransfection of embryo fibroblasts by a human ras oncogene does not convert them into
tumour cells unless the fibroblasts are established and immortalized before transfection. The
embryo fibroblasts become tumorigenic if a second oncogene such as a viral or cellular myc
gene or the gene for the polyoma large-T antigen is introduced together with the ras gene.
tumour cells unless the fibroblasts are established and immortalized before transfection. The
embryo fibroblasts become tumorigenic if a second oncogene such as a viral or cellular myc
gene or the gene for the polyoma large-T antigen is introduced together with the ras gene.
Abstract
Transfection of embryo fibroblasts by a human ras oncogene does not convert them into tumour cells unless the fibroblasts are established and immortalized before transfection. The embryo fibroblasts become tumorigenic if a second oncogene such as a viral or cellular myc gene or the gene for the polyoma large-T antigen is introduced together with the ras gene.
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