The death of retinal ganglion cells during glaucoma is thought to result from damage to their
axons as they exit the eye through the lamina cribrosa. In this study, intraocular pressure in
the rat was increased to twice the normal averge by cauterizing two limbal-derived veins. To
investigate whether retinal ganglion cells in the glaucomatous eye follow an apoptotic type
of death, DNA breaks in nuclei were labeled in situ, using a method that specifically
incorporates biotinylated deoxynucleotides by exogenous terminal deoxynucleotidyl …