Angiogenesis is involved in the pathogenesis of nonrheumatic aortic valve stenosis

Y Soini, T Salo, J Satta - Human pathology, 2003 - Elsevier
Angiogenesis is an essential biological process not only in embryogenesis, but also in the
progression of several major diseases, including cancer, diabetes, and inflammation.
Excessive vascularization can also contribute to some cardiovascular pathologies, such as
atherosclerosis, but contradictory reports still prevail regarding its impact on aortic stenosis.
Using immunohistochemical techniques, we assessed the vascular density and distribution
of angiogenesis (FVIII) and vascular endothelial growth factor (VEGF) expression as well as …