Blocking of iron absorption by a preliminary oral dose of iron
MA O'Neil-Cutting, WH Crosby - Archives of Internal Medicine, 1987 - jamanetwork.com
• Using a small-dose iron tolerance test (ITT) in mildly irondeficient healthy adults, we have
examined the phenomenon of mucosal block. First proposed and demonstrated by Hahn et
al with radioiron," mucosal block" describes diminished avidity for iron of the intestinal
mucosa following an orally administered blocking dose. In the ITT, the index of absorption is
an increase in plasma iron concentration, rather than retained radioactivity. The absorption
of a blocked 10-mg test dose of iron was compared with that of a 10-mg control dose given …
examined the phenomenon of mucosal block. First proposed and demonstrated by Hahn et
al with radioiron," mucosal block" describes diminished avidity for iron of the intestinal
mucosa following an orally administered blocking dose. In the ITT, the index of absorption is
an increase in plasma iron concentration, rather than retained radioactivity. The absorption
of a blocked 10-mg test dose of iron was compared with that of a 10-mg control dose given …
